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Posted by on Oct 31, 2012 in Science |

Canadian scientists discover the cause of high cholesterol

Canadian scientists discover the cause of high cholesterol

The research, presented in the country Cardiovascular Congress earlier today, could be a new road to the prevention and treatment of heart disease. All thanks to the discovery of resistin protein secreted by adipose tissue, which causes high levels of “bad” cholesterol (LDL) and increase the risk of heart disease.

The study concludes that increases low density lipoprotein in human liver cells degrade LDL receptors in the liver. As a result, the liver is unable to remove “bad” in the body. Finally, the researchers say that the protein accelerates the accumulation of LDL in the arteries, increasing the risk of heart disease.

The study also explains that resistin adversely impacts the effects of statins, the cholesterol lowering drug primary used in treatment and prevention of cardiovascular diseases. Shirya Dr. Rashid, author of the study, explained:

It’s amazing, but 40% of people who take statins are resistant to its effects in reducing blood LDL. The larger implication is that our study results is that high levels of resistin may be the cause of the inability of statins to reduce LDL cholesterol in patients.

An expected finding as pathway leading to revolutionary new therapeutic drugs, especially those that target inhibit resistin and increase the effectiveness of statins. According to the researchers:

The possibilities of improved therapy for cardiovascular disease causes are very important. Only in Canada, about 40% of citizens have high levels of cholesterol in the blood, a serious health problem.

And is that high cholesterol is a major risk factor in heart disease and stroke, which can lead to a buildup of plaque in the artery walls and narrowing of the same, causing atherosclerosis, making it difficult for blood to flow through Heart.

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