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Posted by on Dec 14, 2012 in Science |

Discover the key why many tumors recur after chemotherapy

Discover the key why many tumors recur after chemotherapy

A group of researchers at the Princess Margaret Centre in Toronto have come up with a breakthrough in the fight against cancer . Scientists have discovered a key reason that many tumors can recur after chemotherapy . The key, the dormancy of many of the cells that drive tumor growth capable of reviving the disease when they wake up after the end of treatment.

As explained, the finding may provide a new approach to the study and treatment sobe cancer. According to John Dick, chief scientist and research:

We have shown that these cells are hidden from common chemotherapy drugs in a dormant state. From here we need to strengthen the study as it represents a paradigm shift for research of the disease.

Dick, molecular geneticist at the University of Toronto, explains that discovered latent cells have exactly the same genetic mutations that drove the original tumor. Cancer occurs when genetic mutations in the DNA of a cell replicate without control. This cancer can return after chemotherapy because successive genetic mutations that make it resistant to the drugs used against the original tumors:

This is true in many cases, but the discovery of dormant cells genetically identical shows that there are other forces at play in cancer recurrence, and that these forces must be studied from now. What we saw was similar cells or essentially identical to the original, which indicates that there was something else that was driving their resistance to therapy.

The researcher wonders whether these cells are found in the tumor in an area where the latent causes. The scientist explains that together with cancer cells, tumors contain a number of normal tissues, including blood vessels and immune system agents:

And it seems that the tumor cells are in the vicinity of these tumor cells and which can influence their behavior. So that’s one of the properties you seek, seek the reason for this type of latency and receive signals.

He explains that the next step will be to find the formula to kill these cells or control the factors that make them “wake up”, to understand the biological properties, not necessarily genetic, that are driving.

If so, the understanding of these properties could lead to nongenetic a new generation of cancer drugs. Drugs able to wake these cells “asleep” and exposed to chemotherapy.