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Posted by on Nov 28, 2012 in Science |

They manage to reverse the symptoms of autism in mice

They manage to reverse the symptoms of autism in mice

It was a team of researchers from McGill University in Montreal. The scientists managed to relieve the symptoms of Autism in mice by restoring neuronal production of a protein critical. Still, the researchers caution that it is not a cure.

Nor of a drug under development, Canadian scientists do explain that this is a breakthrough by which will build a future study aimed at alleviating a syndrome that affects about one in every 110 people worldwide.

A study that was led by Nahum Sonenberg and that began after researchers developed a mouse model with autism , something extremely difficult if we are trying to “create” a mouse that could accurately reflect human neurological and psychological complexities that transmitted in autism.

These genetically modified had a deficiency in a specific gene called Eif4ebp2. It is the gene responsible for production of the protein called 4E-BP2, which halts the expression of certain messages in the RNA. Then, by removing this gene, researchers were able to create mice brains in producing these proteins above normal levels, which resulted autism-like symptoms in mice, symptoms which contains as little study included social interaction, impaired communication and repetitive behaviors.

Sonenberg explains the mechanics behind the process:

We found that a group of proteins that proliferate in the absence of Eif4ebp2, neuroligins, are arranged in the membrane of neurons and help create and maintain connections between nerve cells. We found that after suppressing the gene responsible for the regulation of these proteins, neuronal levels were above normal.

According Christos Gkogkas, another of the researchers:

Neuroligins are important for communication between neurons. A production too high causes excessive communication between neurons, and in mice causes symptoms such as repetitive behaviors or difficulty relating.

Scientists eventually developed a compound that reduced levels of this protein and completely relieved the symptoms of autism in mice. One step closer to understanding autism that will not result in drugs for humans, but in future studies focused on results. The mouse model does not appear sufficient to test the compound in humans and developed could be too toxic.

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